Table 1 Potencies of chemotherapeutics following siRNA treatment in SKOV-3 cells.
From: Regulators of G-Protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells
| Â | Scrambled siRNA | RGS10 siRNA | RGS17 siRNA | RGS10 + RGS17 siRNA |
|---|---|---|---|---|
Vincristine Potency (nM IC 50 +/- SEM) | 5. 85 +/- 1.3 | 12.8 +/- 2.9 | 58 +/- 8.7 | 24 +/- 4.8 |
Docetaxel Potency (nM IC 50 +/- SEM) | 0.886 +/- 0.432 | 10.7 +/- 3.7 | 85 +/- 23 | 92 +/- 25 |
Cisplatin Potency (μM IC 50 +/- SEM) | 10.4 +/- 1.1 | 23.0 +/- 1.2 | 27.9 +/- 1.2 | 57.8 +/- 1.5 |