Figure 6From: Unscheduled expression of CDC25B in S-phase leads to replicative stress and DNA damageElevated level of CDC25B induces significant chromosomal aberrations. (A) U2OS were induced by tetracycline removal to express Ha-CDC25B (CDC25B) or not (U2OS) during 24 h then chromosomal breaks, gaps and fusions were quantified on metaphase spreads. (B) Representative metaphase spreads with breaks (arrow 1), gaps (arrow 2) and fusions (arrow 3).Back to article page