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Figure 3 | Molecular Cancer

Figure 3

From: The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression

Figure 3

Validation of microarray data by Taqman qRT-PCR. Each pair of graphs relates to one of 16 selected microRNAs differentially expressed in YSTs versus germinomas, of which 12 were over-expressed in YSTs (A) and four over-expressed in germinomas (B). In each pair, the left hand graph shows microarray expression changes in the 25 paediatric tissue samples (12 YSTs, 13 germinomas), referenced to the median expression of eight control samples (fetal and normal gonad [8]). In all cases samples are in the order given in Figure 1, Panel A. Each right hand graph shows data from Taqman qRT-PCR expression analysis in eight tumours (four YSTs and four germinomas) representing a randomly selected subset of the 25 examined by microarray. qRT-PCR expression values are referenced to the sample with the lowest expression level. In all cases samples are in the order: YST-3, YST-4, YST-6, YST-9, Germ-19, Germ-21, Germ-22 and Germ-25.

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