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Figure 3 | Molecular Cancer

Figure 3

From: ZNF217 confers resistance to the pro-apoptotic signals of paclitaxel and aberrant expression of Aurora-A in breast cancer cells

Figure 3

Decreased levels of ZNF217 negatively regulates cell proliferation in vitro. (A) Western-blot analysis of ZNF217 expression in non-transfected (NT) or transfected MDA-MB-231/pcDNA6 cells with either scrambled RNA, siRNA-B or siRNA-A. Histograms represent quantification of protein expression levels normalized to tubulin expression (means ± s.d. of three independent experiments). (B) the same as (A) using the ZNF217-1 cell line. (C) Cell proliferation of non-transfected (NT) or transfected MDA-MB-231/pcDNA6 cells with either scrambled RNA, siRNA-B or siRNA-A as assessed by BrdU test. (D) the same as (C) using the ZNF217-1 cell line. (E) and (F) respectively the same as (A) and (C) using MCF7 cells. *, P < 0.05, **, P < 0.01 and ***, P < 0.001 versus cells transfected with scrambled RNA (Student's t-test).

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