Figure 4

Constitutive expression of ZNF217 stimulates tumor growth in vivo. (A) Growth curves of control xenografts (n = 6) and ZNF217 xenografts (n = 7) in nude mice. Data are presented as means ± s.d. of tumor volumes. *, P < 0.05, **, P < 0.01 and ***, P < 0.001 (Student's t-test). (B) Representative total protein extracts from control and ZNF217 xenografts were analyzed by western-blot with anti-ZNF217 and anti-Cyclin D1 antibodies. Histogram represents quantification of protein expression levels normalized to tubulin expression (means ± s.d. of three independent experiments). ***, P < 0.001 (Student's t-test).