Figure 1From: Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genesAnalyses of genes regulated by oncogenic KRAS, HIF-1α, HIF-2α, and both HIF-1α and HIF-2α. Expression of target genes in HCT116, HCT116HIF-1α-/-, HCT116HIF-2α-/-, HCT116HIF-1α-/-HIF-2α-/-, and HCT116WT KRAS cell lines. HK2, hexokinase 2; LDHA, lactate dehydrogenase A; MGLL, monoglyceride lipase; ANGPTL4, angiopoietin-like protein 4; and VEGFA, vascular endothelial growth factor A relative to β-actin were measured by real-time reverse transcription-PCR (n = 5). Bars, stdev. p < 0.05 by Student's t test comparing knockout cells with parental HCT116 cells. c, clone.Back to article page