Sigma-2 ligands have high affinity for pancreas cancer and decrease viability. A. Chemical structures of sigma-2 ligands. B. Representative competitive binding data for inhibition of [125I]-ISO-2 binding to sigma-2 receptors in Panc02 tumor membrane homogenates. IC50 for binding affinities are pentazocine 1381 ± 33 nM, siramesine 1.9 ± 0.1 nM, SV119 7.8 ± 1.7 nM, and SW43 18 ± 2.1 nM. C. Pancreas cancer cell lines were treated with escalating doses of the sigma-2 ligands SV119, SW43, and siramesine (SRM) or DMSO vehicle for 18 hours and viability relative to vehicle determined by CellTiter-Glo Luminescent Viability Assay (Promega).