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Figure 4 | Molecular Cancer

Figure 4

From: The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine

Figure 4

Sigma-2 ligands enhance gemcitabine induced cell death in pancreas cancer. Multiple pancreatic cancer cell lines, including Cfpac, Panc1, BxPC3 (Table 1), and Panc02 (shown) were treated with DMSO vehicle or sigma-2 ligands (25 μM) SV119, SW43, or siramesine (SRM) following 24 hour pre-treatment with gemcitabine (0.5 μM). Eighteen hours later cell viability was determined using the CellTiter-Glo Luminescent Viability Assay (Promega), (mean ± SEM), n ≥ 3.

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