Sigma-2 ligands decrease Panc02 tumor burden in C57BL/6. One million Panc02 cells were inoculated subcutaneously into female, 10 week old C57BL/6 mice and when tumors had reached a mean diameter of 5 mm, daily sigma-2 ligand treatment with or without weekly gemcitabine began by IP injection. All treatments decreased tumor volume compared to DMSO vehicle alone, p < 0.001. A. Siramesine (SRM) treatment did not confer a significantly different tumor volume than gemcitabine alone, *p > 0.05. Single agent sigma-2 ligands SV119 B. and SW43 C. decreased tumor volume similar to gemcitabine, *p > 0.05, while combination therapy produced much smaller tumors, **p < 0.001.