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Figure 2 | Molecular Cancer

Figure 2

From: Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo

Figure 2

Inhibition of anchorage-independent growth by anti-MCSP:TRAIL. A A375M and A2058 cells were treated with increasing concentrations of anti-MCSP:TRAIL for 21 days and colony formation was assessed. B A375M cells were treated with increasing concentrations of anti-MCSP:TRAIL, anti-EpCAM:TRAIL, anti-MCSP mAb or anti-EpCAM:TRAIL+anti-MCSP mAb for 21 days and colony formation was assessed. C A375M cells were treated with rhTRAIL, anti-EpCAM:TRAIL or anti-MCSP:TRAIL for 21 days and colony formation was assessed. D A375M cells were treated with 100 ng/ml anti-MCSP:TRAIL in the absence or presence of TRAIL-neutralizing mAb 2E5, parental anti-MCSP mAb 9.2.27 or pan-caspase inhibitor zVAD-fmk for 21 days and colony formation was assessed. E A375M and A375M.FADD-DED cells were treated with increasing concentrations of anti-MCSP:TRAIL for 21 days and colony formation was assessed. F A375M.FADD-DED cells were treated with increasing concentrations of anti-MCSP:TRAIL, anti-EpCAM:TRAIL, anti-MCSP mAb or anti-EpCAM:TRAIL+anti-MCSP mAb for 21 days and colony formation was assessed.

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