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Figure 6 | Molecular Cancer

Figure 6

From: Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo

Figure 6

Schematic representation of the anti-melanoma activity of anti-MCSP:TRAIL. A Direct or indirect MCSP-mediated signaling involves (integrin-dependent) FAK and Src phosphorylation and maintains phosphorylation of downstream transcription factors and apoptotic modulators. MCSP thus contributes to pro-survival and metastatic signals. B Binding of anti-MCSP:TRAIL inhibits MCSP-mediated signaling and concomitant activation of pro-metastatic/-survival signals and thereby sensitizes cells to apoptosis induction via binding of the TRAIL moiety to TRAILR.

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Molecular Cancer

ISSN: 1476-4598