Figure 5From: HTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progressionThe progression through G1/S transition in the presence or absence of HTLV-1 p30. HTLV-1 p30 disrupts the interaction between CDK2 and Cylin E and the capacity of this complex to phosphorylate Rb. E2F becomes sequestered by Rb and is not available to activate the expression of genes involved in G1/S transition.Back to article page