Figure 5From: Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiationCell cycle, DNMT inhibitors and radiosensitivity. The radiosensitivity of cells is dependent on the phase of the cell cycle. Cells in the S phase are the most radio resistant, and cells in the G2-M phase of the cell cycle are the most radiosensitive. DNMT inhibitors synchronize with the cell cycle of tumor cells increasing the efficacy of subsequent radiotherapy.Back to article page