Table 1 The inhibition of β-catenin expression by ShRNA or MSeA is associated with drug-induced growth inhibition of tumor cells
HCT-8 cell line | % cell growth inhibition | Beta-catenin expression |
|---|---|---|
Control | 0% | ++++/strong |
MSeA (1 μM) | ~50% | ++/weak |
SN-38(0.7 μM) | ~20% | ++++/strong |
MSeA+SN-38 | >95% | +/very weak |
ShRNA | 0% | ++/weak |
ShRNA+SN38 | ~70% | +/very weak |