Figure 1

Rab GTPases are involved in vesicle transport and trafficking. Some examples of Rab functions are shown. Rab 1a is localized pre-Golgi intermediates, and Rab 1b, 2a and 2b, which are localized in the ER, are important in transport from the ER to Golgi. Rab6a, 6b, and 33b are involved in intra-Golgi transport, as well as transport from the Golgi apparatus to the ER. Rab 11a and Rab17 are involved in transport through apical recycling endosomes. Rab14 and 22a contribute to transport from phagosomes to late endosomes. Rab9a, 9b, and 9c are involved in late endosome to Golgi transport. Rab7b participates in transport from endosomes to the TGN, while Rab12 is involved in transport from the cell periphery to the centrosome. Rab 5 and 14 are localized in early endosome and Rab 4 is localized in recycled enodosmes. Rab18 is involved in transport from ER to lipid droplets; Rab10, from Golgi to the basolateral membrane; Rab 26, 27a, 27b, 37, 11b and 3a-d, from Golgi to secretory granules; Rab22b and Rab11a, from Golgi to endosomes; and Rab6a', 22a and 14, from endosomes to Golgi. Rab 32 is localized in mitochondria and regulates mitochondrial dynamics.