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Figure 2 | Molecular Cancer

Figure 2

From: Integrin-mediated function of Rab GTPases in cancer progression

Figure 2

Role of Rab25 in cancer. Activated Rab 25 and other growth factor receptors are located near the cell surface. Rab25 regulates receptor internalization, vesicle formation, and trafficking with specific cellular components. Rab25 also activates AKT, which increases cell proliferation and survival. Rab25 integration leads to down-regulation of BAX and BAK to activate the Bcl2 pathway, which affects apoptosis and cell survival.

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