Skip to main content

Table 1 PCR Array analysis† showing top 10 endogenously upregulated (p ≤ 0.05) genes in human MM cell lines (MO, ME-26) compared to untransformed LP9/TERT1 mesothelial cells

From: Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin

Gene name (symbol) Function Fold Increase (MO) Fold Increase (ME-26)
   -UO126 +UO126 20 μM -UO126 +UO126 20 μM
B-cell CLL/Lymphoma (BCL2)* Drug Resistance 213.65 127.7§ 28.92 14.57§
V-fos FBJ murine osteosarcoma viral oncogene homolog (FOS)* Transcription Factor 26.52 2.28§ 33.85 20.59§
Met protooncogene (MET) Growth Factor Receptor 25.45 28.09 27.60 25.42
ATP-binding cassette (MDR/TAP) (ABCB1) Drug Resistance 13.6 4.66   
Estrogen receptor 1 (ESR1) Hormone Receptors 11.03 10.90   
Breast cancer 1, early onset (BRCA1) DNA Repair 6.66 1.42‡,§ 6.68 2.88§
Androgen receptor (AR) Hromone Receptors 6.35 10.25§   
Estrogen receptor 2 (ESR2) Hormone Receptor 4.19 10.48§ 4.53 6.15
Breast cancer 2, early onset (BRCA2) DNA Repair 3.98 2.21 5.18 2.64§
Cyclin-dependent kinase inhibitor 2D (CDKN2D) Cell Cycle 3.68 4.88   
Cytochrome P450 (CYP3A4) Drug Metabolism    77.12 25.06§
Peroxisome proliferative activated receptor, gamma (PPARγ) Hormone Receptor    9.72 4.55§
Tumor protein 53 (TP53) Drug Resistance    4.35 4.52
ATP-binding cassette (ABCC3) Drug Resistance    4.56 2.26§
*Validation by qRT-PCR      
Gene name (symbol) Function Validation (MO) Validation (ME-26)
   -UO126 +UO126 -UO126 20 μM +UO126 20 μM
B-cell CLL/Lymphoma (BCL2) Drug Resistance 550 476 123 31
V-fos FBJ murine osteosacroma viral oncogene homolog (FOS) Transcription Factor 16 2.14 23.88 8.9
  1. SABiosciences: Human drug resistance and metabolism template
  2. Not significantly different from LP9
  3. §Significantly different from -UO126 group of the respective cell line