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Table 2 Microarray analysis showing endogenous expression of ATP-binding cassette genes in shERK1 and shERK2 cells compared to shControl, stable HMESO cells (p ≤ 0.05)

From: Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin

Gene name(symbol)

Fold Change shERK1 vs. shCon

Fold Change shERK2 vs. shCon

ATP-binding cassette, subfamily G (WHITE), member 1 (ABCG1)

-4.89

 

ATP-binding cassette, subfamily A (ABC1), member 5 (ABCA5)*

-2.77

 

ATP-binding cassette, subfamily A (ABC1), member 2 (ABCA2)*†

-2.13

 

Transporter 2, ATP-binding cassette, subfamily B (MDR/TAP)†

-2.09

 

ATP-binding cassette, subfamily A (ABC), member 1 (ABCA1)

-2.06

 

ATP-binding cassette, subfamily A (ABC1), member 8 (ABCA8)*

 

-2.38

ATP-binding cassette, subfamily C (CFTR/MRP), member 2 (ABCC2)*†

 

-2.19

*Validation by qRT-PCR

  

Gene name(symbol)

Fold Change shERK1 vs. shCon

Fold Change shERK2 vs. shCon

ABCA2

-2.88

 

ABCA5

-3.6

 

ABCA8

 

-3.4

ABCC2

 

-3.0

  1. † Indicates Doxorubicin is a substrate as reported in the literature.