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Table 2 Microarray analysis showing endogenous expression of ATP-binding cassette genes in shERK1 and shERK2 cells compared to shControl, stable HMESO cells (p ≤ 0.05)

From: Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin

Gene name(symbol) Fold Change shERK1 vs. shCon Fold Change shERK2 vs. shCon
ATP-binding cassette, subfamily G (WHITE), member 1 (ABCG1) -4.89  
ATP-binding cassette, subfamily A (ABC1), member 5 (ABCA5)* -2.77  
ATP-binding cassette, subfamily A (ABC1), member 2 (ABCA2)* -2.13  
Transporter 2, ATP-binding cassette, subfamily B (MDR/TAP)† -2.09  
ATP-binding cassette, subfamily A (ABC), member 1 (ABCA1) -2.06  
ATP-binding cassette, subfamily A (ABC1), member 8 (ABCA8)*   -2.38
ATP-binding cassette, subfamily C (CFTR/MRP), member 2 (ABCC2)*   -2.19
*Validation by qRT-PCR   
Gene name(symbol) Fold Change shERK1 vs. shCon Fold Change shERK2 vs. shCon
ABCA2 -2.88  
ABCA5 -3.6  
ABCA8   -3.4
ABCC2   -3.0
  1. † Indicates Doxorubicin is a substrate as reported in the literature.