TY - JOUR AU - Hanahan, D. AU - Folkman, J. PY - 1996 DA - 1996// TI - Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis JO - Cell VL - 86 UR - https://doi.org/10.1016/S0092-8674(00)80108-7 DO - 10.1016/S0092-8674(00)80108-7 ID - Hanahan1996 ER - TY - JOUR AU - Folkman, J. PY - 2006 DA - 2006// TI - Angiogenesis JO - Annu Rev Med VL - 57 UR - https://doi.org/10.1146/annurev.med.57.121304.131306 DO - 10.1146/annurev.med.57.121304.131306 ID - Folkman2006 ER - TY - JOUR AU - Ruan, K. AU - Song, G. AU - Ouyang, G. PY - 2009 DA - 2009// TI - Role of hypoxia in the hallmarks of human cancer JO - J Cell Biochem VL - 107 UR - https://doi.org/10.1002/jcb.22214 DO - 10.1002/jcb.22214 ID - Ruan2009 ER - TY - JOUR AU - Semenza, G. L. PY - 2009 DA - 2009// TI - HIF-1 inhibitors for cancer therapy: from gene expression to drug discovery JO - Curr Pharm Des VL - 15 UR - https://doi.org/10.2174/138161209789649402 DO - 10.2174/138161209789649402 ID - Semenza2009 ER - TY - JOUR AU - Ferrara, N. PY - 1999 DA - 1999// TI - Role of vascular endothelial growth factor in the regulation of angiogenesis JO - Kidney Int VL - 56 UR - https://doi.org/10.1046/j.1523-1755.1999.00610.x DO - 10.1046/j.1523-1755.1999.00610.x ID - Ferrara1999 ER - TY - JOUR AU - Ferrara, N. PY - 2004 DA - 2004// TI - Vascular endothelial growth factor: basic science and clinical progress JO - Endocr Rev VL - 25 UR - https://doi.org/10.1210/er.2003-0027 DO - 10.1210/er.2003-0027 ID - Ferrara2004 ER - TY - JOUR AU - Kranenburg, O. AU - Gebbink, M. F. AU - Voest, E. E. PY - 2004 DA - 2004// TI - Stimulation of angiogenesis by Ras proteins JO - Biochim Biophys Acta VL - 1654 ID - Kranenburg2004 ER - TY - JOUR AU - Rafii, S. AU - Lyden, D. AU - Benezra, R. AU - Hattori, K. AU - Heissig, B. PY - 2002 DA - 2002// TI - Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? JO - Nat Rev Cancer VL - 2 UR - https://doi.org/10.1038/nrc925 DO - 10.1038/nrc925 ID - Rafii2002 ER - TY - JOUR AU - Jain, R. K. PY - 2008 DA - 2008// TI - Lessons from multidisciplinary translational trials on anti-angiogenic therapy of cancer JO - Nat Rev Cancer VL - 8 UR - https://doi.org/10.1038/nrc2346 DO - 10.1038/nrc2346 ID - Jain2008 ER - TY - JOUR AU - Ferrara, N. AU - Kerbel, R. S. PY - 2005 DA - 2005// TI - Angiogenesis as a therapeutic target JO - Nature VL - 438 UR - https://doi.org/10.1038/nature04483 DO - 10.1038/nature04483 ID - Ferrara2005 ER - TY - JOUR AU - Tee, M. K. AU - Jaffe, R. B. PY - 2001 DA - 2001// TI - A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon JO - Biochem J VL - 359 UR - https://doi.org/10.1042/bj3590219 DO - 10.1042/bj3590219 ID - Tee2001 ER - TY - JOUR AU - Ladomery, M. R. AU - Harper, S. J. AU - Bates, D. O. PY - 2007 DA - 2007// TI - Alternative splicing in angiogenesis: the vascular endothelial growth factor paradigm JO - Cancer Lett VL - 249 UR - https://doi.org/10.1016/j.canlet.2006.08.015 DO - 10.1016/j.canlet.2006.08.015 ID - Ladomery2007 ER - TY - JOUR AU - Harper, S. J. AU - Bates, D. O. PY - 2008 DA - 2008// TI - VEGF-A splicing: the key to anti-angiogenic therapeutics? JO - Nat Rev Cancer VL - 8 UR - https://doi.org/10.1038/nrc2505 DO - 10.1038/nrc2505 ID - Harper2008 ER - TY - JOUR AU - Woolard, J. AU - Wang, W. Y. AU - Bevan, H. S. AU - Qiu, Y. AU - Morbidelli, L. AU - Pritchard-Jones, R. O. AU - Cui, T. G. AU - Sugiono, M. AU - Waine, E. AU - Perrin, R. AU - Foster, R. AU - Digby-Bell, J. AU - Shields, J. D. AU - Whittles, C. E. AU - Mushens, R. E. AU - Gillatt, D. A. AU - Ziche, M. AU - Harper, S. J. AU - Bates, D. O. PY - 2004 DA - 2004// TI - VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression JO - Cancer Res VL - 64 UR - https://doi.org/10.1158/0008-5472.CAN-04-0934 DO - 10.1158/0008-5472.CAN-04-0934 ID - Woolard2004 ER - TY - JOUR AU - Rennel, E. S. AU - Varey, A. H. AU - Churchill, A. J. AU - Wheatley, E. R. AU - Stewart, L. AU - Mather, S. AU - Bates, D. O. AU - Harper, S. J. PY - 2009 DA - 2009// TI - VEGF(121)b, a new member of the VEGF(xxx)b family of VEGF-A splice isoforms, inhibits neovascularisation and tumour growth in vivo JO - Br J Cancer VL - 101 UR - https://doi.org/10.1038/sj.bjc.6605249 DO - 10.1038/sj.bjc.6605249 ID - Rennel2009 ER - TY - JOUR AU - Kawamura, H. AU - Li, X. AU - Harper, S. J. AU - Bates, D. O. AU - Claesson-Welsh, L. PY - 2008 DA - 2008// TI - Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-07-6577 DO - 10.1158/0008-5472.CAN-07-6577 ID - Kawamura2008 ER - TY - JOUR AU - Glass, C. A. AU - Harper, S. J. AU - Bates, D. O. PY - 2006 DA - 2006// TI - The anti-angiogenic VEGF isoform VEGF165b transiently increases hydraulic conductivity, probably through VEGF receptor 1 in vivo JO - J Physiol VL - 572 UR - https://doi.org/10.1113/jphysiol.2005.103127 DO - 10.1113/jphysiol.2005.103127 ID - Glass2006 ER - TY - JOUR AU - Varey, A. H. AU - Rennel, E. S. AU - Qiu, Y. AU - Bevan, H. S. AU - Perrin, R. M. AU - Raffy, S. AU - Dixon, A. R. AU - Paraskeva, C. AU - Zaccheo, O. AU - Hassan, A. B. AU - Harper, S. J. AU - Bates, D. O. PY - 2008 DA - 2008// TI - VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy JO - Br J Cancer VL - 98 UR - https://doi.org/10.1038/sj.bjc.6604308 DO - 10.1038/sj.bjc.6604308 ID - Varey2008 ER - TY - JOUR AU - Bates, D. O. AU - Cui, T. G. AU - Doughty, J. M. AU - Winkler, M. AU - Sugiono, M. AU - Shields, J. D. AU - Peat, D. AU - Gillatt, D. AU - Harper, S. J. PY - 2002 DA - 2002// TI - VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma JO - Cancer Res VL - 62 ID - Bates2002 ER - TY - JOUR AU - Birkenhager, R. AU - Schneppe, B. AU - Rockl, W. AU - Wilting, J. AU - Weich, H. A. AU - McCarthy, J. E. PY - 1996 DA - 1996// TI - Synthesis and physiological activity of heterodimers comprising different splice forms of vascular endothelial growth factor and placenta growth factor JO - Biochem J VL - 316 UR - https://doi.org/10.1042/bj3160703 DO - 10.1042/bj3160703 ID - Birkenhager1996 ER - TY - JOUR AU - Claffey, K. P. AU - Senger, D. R. AU - Spiegelman, B. M. PY - 1995 DA - 1995// TI - Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF JO - Biochim Biophys Acta VL - 1246 UR - https://doi.org/10.1016/0167-4838(94)00144-6 DO - 10.1016/0167-4838(94)00144-6 ID - Claffey1995 ER - TY - JOUR AU - Pietras, K. AU - Ostman, A. PY - 2010 DA - 2010// TI - Hallmarks of cancer: interactions with the tumor stroma JO - Exp Cell Res VL - 316 UR - https://doi.org/10.1016/j.yexcr.2010.02.045 DO - 10.1016/j.yexcr.2010.02.045 ID - Pietras2010 ER - TY - JOUR AU - Rennel, E. AU - Waine, E. AU - Guan, H. AU - Schuler, Y. AU - Leenders, W. AU - Woolard, J. AU - Sugiono, M. AU - Gillatt, D. AU - Kleinerman, E. AU - Bates, D. AU - Harper, S. PY - 2008 DA - 2008// TI - The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice JO - Br J Cancer VL - 98 UR - https://doi.org/10.1038/sj.bjc.6604309 DO - 10.1038/sj.bjc.6604309 ID - Rennel2008 ER - TY - JOUR AU - Rennel, E. S. AU - Hamdollah-Zadeh, M. A. AU - Wheatley, E. R. AU - Magnussen, A. AU - Schuler, Y. AU - Kelly, S. P. AU - Finucane, C. AU - Ellison, D. AU - Cebe-Suarez, S. AU - Ballmer-Hofer, K. AU - Mather, S. AU - Stewart, L. AU - Bates, D. O. AU - Harper, S. J. PY - 2008 DA - 2008// TI - Recombinant human VEGF165b protein is an effective anti-cancer agent in mice JO - Eur J Cancer VL - 44 UR - https://doi.org/10.1016/j.ejca.2008.05.027 DO - 10.1016/j.ejca.2008.05.027 ID - Rennel2008 ER - TY - JOUR AU - Pritchard-Jones, R. O. AU - Dunn, D. B. AU - Qiu, Y. AU - Varey, A. H. AU - Orlando, A. AU - Rigby, H. AU - Harper, S. J. AU - Bates, D. O. PY - 2007 DA - 2007// TI - Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma JO - Br J Cancer VL - 97 UR - https://doi.org/10.1038/sj.bjc.6603839 DO - 10.1038/sj.bjc.6603839 ID - Pritchard-Jones2007 ER - TY - JOUR AU - Schumacher, V. A. AU - Jeruschke, S. AU - Eitner, F. AU - Becker, J. U. AU - Pitschke, G. AU - Ince, Y. AU - Miner, J. H. AU - Leuschner, I. AU - Engers, R. AU - Everding, A. S. AU - Bulla, M. AU - Royer-Pokora, B. PY - 2007 DA - 2007// TI - Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndrome JO - J Am Soc Nephrol VL - 18 UR - https://doi.org/10.1681/ASN.2006020124 DO - 10.1681/ASN.2006020124 ID - Schumacher2007 ER - TY - JOUR AU - Zhang, Y. AU - Furumura, M. AU - Morita, E. PY - 2008 DA - 2008// TI - Distinct signaling pathways confer different vascular responses to VEGF 121 and VEGF 165 JO - Growth Factors VL - 26 UR - https://doi.org/10.1080/08977190802105909 DO - 10.1080/08977190802105909 ID - Zhang2008 ER - TY - JOUR AU - Shenberger, J. S. AU - Zhang, L. AU - Powell, R. J. AU - Barchowsky, A. PY - 2007 DA - 2007// TI - Hyperoxia enhances VEGF release from A549 cells via post-transcriptional processes JO - Free Radic Biol Med VL - 43 UR - https://doi.org/10.1016/j.freeradbiomed.2007.05.033 DO - 10.1016/j.freeradbiomed.2007.05.033 ID - Shenberger2007 ER - TY - JOUR AU - Fang, J. AU - Zhou, Q. AU - Liu, L. Z. AU - Xia, C. AU - Hu, X. AU - Shi, X. AU - Jiang, B. H. PY - 2007 DA - 2007// TI - Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression JO - Carcinogenesis VL - 28 UR - https://doi.org/10.1093/carcin/bgl205 DO - 10.1093/carcin/bgl205 ID - Fang2007 ER - TY - JOUR AU - Akhtar, S. AU - Meeran, S. M. AU - Katiyar, N. AU - Katiyar, S. K. PY - 2009 DA - 2009// TI - Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors JO - Clin Cancer Res VL - 15 UR - https://doi.org/10.1158/1078-0432.CCR-08-1901 DO - 10.1158/1078-0432.CCR-08-1901 ID - Akhtar2009 ER - TY - JOUR AU - Westphal, J. R. AU - Van't Hullenaar, R. AU - Peek, R. AU - Willems, R. W. AU - Crickard, K. AU - Crickard, U. AU - Askaa, J. AU - Clemmensen, I. AU - Ruiter, D. J. AU - De Waal, R. M. PY - 2000 DA - 2000// TI - Angiogenic balance in human melanoma: expression of VEGF, bFGF, IL-8, PDGF and angiostatin in relation to vascular density of xenografts in vivo JO - Int J Cancer VL - 86 UR - https://doi.org/3.0.CO;2-E DO - 3.0.CO;2-E ID - Westphal2000 ER - TY - JOUR AU - Sumimoto, H. AU - Imabayashi, F. AU - Iwata, T. AU - Kawakami, Y. PY - 2006 DA - 2006// TI - The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells JO - J Exp Med VL - 203 UR - https://doi.org/10.1084/jem.20051848 DO - 10.1084/jem.20051848 ID - Sumimoto2006 ER - TY - JOUR AU - Dang, D. T. AU - Chun, S. Y. AU - Burkitt, K. AU - Abe, M. AU - Chen, S. AU - Havre, P. AU - Mabjeesh, N. J. AU - Heath, E. I. AU - Vogelzang, N. J. AU - Cruz-Correa, M. AU - Blayney, D. W. AU - Ensminger, W. D. AU - St Croix, B. AU - Dang, N. H. AU - Dang, L. H. PY - 2008 DA - 2008// TI - Hypoxia-inducible factor-1 target genes as indicators of tumor vessel response to vascular endothelial growth factor inhibition JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-07-1589 DO - 10.1158/0008-5472.CAN-07-1589 ID - Dang2008 ER - TY - JOUR AU - Guan, H. AU - Zhou, Z. AU - Wang, H. AU - Jia, S. F. AU - Liu, W. AU - Kleinerman, E. S. PY - 2005 DA - 2005// TI - A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model JO - Clin Cancer Res VL - 11 UR - https://doi.org/10.1158/1078-0432.CCR-04-1206 DO - 10.1158/1078-0432.CCR-04-1206 ID - Guan2005 ER -