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Figure 2 | Molecular Cancer

Figure 2

From: Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation

Figure 2

The effect of pentamidine on IR-induced cellular response. (A) Pentamidine repressed γ-H2AX foci formation. MRC5SV cells were irradiated with 5 Gy of γ-ray with or without pre-treatment of pentamidine (indicated concentrations, 30 minutes). After 30 minutes, their cells were fixed and immuno-staining was performed using anti-γ-H2AX. Percentage of γ-H2AX foci-positive cell was shown in (B). (C) Pentamidine repressed focus formation of DNA damage-related factors. MRC5SV cells were irradiated with 5 Gy of γ-ray with or without pre-treatment of pentamidine (0.5 mM, 30 minutes). After 30 minutes, their cells were fixed and immuno-staining was performed using anti-NBS1, anti-phospho-ATM, anti-hMRE11 and anti-MDC1 antibodies.

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Molecular Cancer

ISSN: 1476-4598