Results of survival rate with immunohistochemical variables in different disease stages (n = 39). A. In the early disease stage, the number of CD8+ cells (A and C) and the ratio of CD8+TIL to Foxp3+ TIL (B and D) are significantly associated with PFS (P < 0.05). B. In the late disease stage, the number of Foxp3+ cells (A and C) and Foxp3+ together with GrB+ cells (B and D) are significantly associated with OS (P < 0.01) and PFS (P < 0.01).