Table 6 Multivariate analysis of factors for the ratio of CD8⁺ TIL to Foxp3⁺ TIL and Foxp3⁺ TIL combined with Granzyme B⁺ TIL with survival

The ratio of CD8 to Foxp3

Tumor (T) stage (4+3/2+1)

1.007

0.419-2.420

0.988

1.185

0.523-2.686

0.685

Nodal (N) status (3+2+1/0)

4.172

0.545-31.939

0.169

2.821

0.655-12.154

0.164

TNM stage (III+IVa+IVb/I+II)

2.444

0.754-7.928

0.136

1.561

0.569-4.286

0.387

CD8/Foxp3 (high/low)

1.898

0.885-4.071

0.100

2.393

1.174-4.874

0.016*

Combination of Foxp3 and GrB

Tumor (T) stage (4+3/2+1)

0.647

0.256-1.639

0.359

0.750

0.318-1.768

0.510

Nodal (N) status (3+2+1/0)

5.798

0.757-44.421

0.091

4. 681

1.080-20.280

0.039*

TNM stage (III+IVa+IVb/I+II)

3.078

0.940-10.075

0.063

2.093

0.759-5.78

0.153

Combination of Foxp3 ⁺ and Granzyme B ⁺ TIL

Overall

NA

0.028*

NA

0.001*

Foxp3GrB high VS Foxp3GrB low

0.314

0.111-0.887

0.029*

0.197

0.072-0.540

0.002*