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Table 2 Relative activities of the forward and the reverse promoters of BRCA2 gene in different unsynchronized human breast cancer cells at 95% confluency.

From: Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells

Promoter orientation

Relative luciferase activity* in

 

MCF-7

MDA-MB-468

MDA-MB-231

BT549

Forward

2.6 ±0.7

0.9 ± 0.2

1.6 ± 0.2

3.0 ± 0.5

Reverse

22.0 ± 2.1

5.4 ± 0.3

8.7 ± 0.8

15.4 ± 0.1

  1. *Renilla luciferase activities are expressed as relative light units (RLU) normalized with respect to firefly luciferase activities from the same cellular extracts. Results are mean ± SE (n = 6).
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Molecular Cancer

ISSN: 1476-4598