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Table 2 Relative activities of the forward and the reverse promoters of BRCA2 gene in different unsynchronized human breast cancer cells at 95% confluency.

From: Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells

Promoter orientation Relative luciferase activity* in
  MCF-7 MDA-MB-468 MDA-MB-231 BT549
Forward 2.6 ±0.7 0.9 ± 0.2 1.6 ± 0.2 3.0 ± 0.5
Reverse 22.0 ± 2.1 5.4 ± 0.3 8.7 ± 0.8 15.4 ± 0.1
  1. *Renilla luciferase activities are expressed as relative light units (RLU) normalized with respect to firefly luciferase activities from the same cellular extracts. Results are mean ± SE (n = 6).
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Molecular Cancer

ISSN: 1476-4598