Survival curve for the four weeks DEN protocol. A. Schematic diagram is depicted for the four weeks DEN protocol. Mice were injected at four weeks of age with a single DEN injection (100 mg/Kg). At eight weeks of age the tumor promoter, 0.07% phenobarbital was provided in the drinking water in 5% sucrose. B. Mice survival was followed until eleven months of age. The survival of wild type (n = 23, dotted line) versus JDP2-transgenic (n = 24, solid line). Kaplan-Meier analysis performed shows P value < 0.05.