Liver pathology of eleven months old DEN injected mice. Liver/body weight ratio (A.) and Serum ALT (B.) was determined from eleven months old of either wild type control (wt) or JDP2-transgenic (tg) mice. The results represent the average and SEM of the indicated number of animals (n). C. The number of macroscopic tumors (Y axis) and their corresponding size are drawn for each mouse (X axis). The circle size corresponds to the tumor diameter according to the centimeter scale provided at the bottom of the figure. Student's t-test P value < 0.01 D. H&E staining of representative liver sections of DEN injected eleven months old either wild type control (wt) or JDP2-transgenic (tg).