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Figure 5 | Molecular Cancer

Figure 5

From: The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice

Figure 5

JDP2 role in tumor initiation following DEN injection. Mice were either not treated (0 h) or injected with DEN 100 mg/Kg and sacrificed 24 h and 48 h following injection. Serum ALT (A.) and Liver/body weight ratio (B.) were determined in wild type (wt, black bar) and JDP2-transgenic (tg, grey bar). The results represent the average and SEM of the indicated number of animals (n). C. The expression level of the indicated genes was determined by Real time qPCR to the indicated selected genes from cDNA derived from mRNA prepared from liver tissue of either wild type control (wt) or JDP2-transgenic (tg). The expression level of each gene was normalized by the 18s ribosomal RNA and β2-microglobulin mRNA. The mRNA derived from either non-injected (taken from data set Figure 2D) or mice injected with DEN (100 mg/Kg) sacrificed 24 h thereafter. The results represent the calculated expression ratio between JDP-transgenic divided by the expression level of the corresponding gene in the wild type mice. The average and SEM of three different experiments performed with pooled mRNA from the 0 h-n [tg = 4/wt = 5] and 24 h-n [tg = 3/wt = 2] animals.

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