Figure 1
From: Wnt-11 promotes neuroendocrine-like differentiation, survival and migration of prostate cancer cells
Wnt-11 protein expression in prostate and prostate cancer. Immunohistochemical analysis of Wnt-11 in (a) benign prostate; faint cytoplasmic expression (black arrow) and stromal smooth muscle (red arrow) are indicated, (b-d) examples of Gleason 4 tumours, (e) Gleason 4 tumour with perineural invasion (inset arrowed), (f) a strongly positive Gleason 5 tumour, (g, h) adjacent sections of a prostate cancer bone metastasis showing Wnt-11 (g) and androgen receptor (AR, h), and (i, j) adjacent sections of a Gleason 4 tumour showing Wnt-11 (i) and AR (j); arrows show PCa cell co-expressing Wnt-11 and nuclear AR. Scale bar (a-f, i, j): 50 μm, (g, h, left to right): 200 μm, 75 μm and 25 μm.