Wnt-11 promotes prostate cancer cell migration and invasion. (a) PC3 cells were transfected for 72 hours with control or WNT11 siRNAs, plated on Transwell filters and the extent of migration determined. WNT11 siRNA decreased transverse migration (p = 0.02; n = 9). Results are plotted as Migration Index (Mi), which is the percentage of migrated cells compared to the total number of cells seeded. (b) LNCaP cells were transfected with empty vector or Wnt-11 expression plasmid, plated on Matrigel-coated transwell filters and the extent of invasion determined. The extent of invasion was normalised to that in control cells (p = 0.01; n = 5). The total cell number did not change during the course of the experiment.