| |
RB1
|
LIMD1
|
|---|
|
Sample No.; HPV status
|
Genetic alterations
|
mRNA status
|
Protein expression
|
Genetic/epigenetic alterations
|
mRNA status
|
|---|
|
Dysplastic lesions
| | | | | |
|
L127; HPV-
|
D-
|
ND
|
Normal
|
D+Me+Mu-
|
ND
|
|
L139; HPV-
|
D-
|
ND
|
Normal
|
D-Me+Mu-
|
ND
|
|
L154; HPV-
|
D-
|
ND
|
Normal
|
D+Me+Mu-
|
ND
|
|
L162; HPV-
|
D-
|
ND
|
Normal
|
D+Me+Mu-
|
ND
|
|
L158; HPV16
|
D-
|
ND
|
Medium
|
D+Me+Mu-
|
ND
|
|
HNSCC samples
| | | | | |
|
#1004; HPV-
|
D-
|
Normal
|
Normal
|
D+Me+Mu-
|
↓
|
|
#5165; HPV-
|
D-
|
Normal
|
Normal
|
D+Me+Mu-
|
↓
|
|
#6817;HPV16
|
D+
|
↓
|
Medium
|
D+Me+Mu-
|
↓
|
|
#2884; HPV-
|
D-
|
Normal
|
Normal
|
D-Me-Mu-
|
Normal
|
|
#1108; HPV -
|
D+
|
↓
|
Medium
|
D-Me+Mu+
|
↓
|
|
#1774;HPV16
|
D+
|
↓
|
Low
|
D-Me+Mu+
|
↓
|
|
#872; HPV-
|
D-
|
Normal
|
Normal
|
D-Me-Mu-
|
Normal
|
|
#5303; HPV-
|
D-
|
Normal
|
Normal
|
D-Me+Mu+
|
↓
|
|
#6907;HPV16
|
D-
|
↓
|
Low
|
D-Me+Mu-
|
↓
|
|
#1087; HPV-
|
D-
|
Normal
|
Normal
|
D-Me-Mu+
|
Normal
|
|
#944; HPV-
|
D+
|
↓
|
Low
|
D+Me+Mu+
|
↓
|
|
#5733;HPV16
|
D-
|
Normal
|
Normal
|
D+Me+Mu-
|
↓
|
|
#6392; HPV-
|
D-
|
Normal
|
Normal
|
D-Me+Mu-
|
↓
|
|
#7077; HPV-
|
D-
|
Normal
|
Normal
|
D-Me-Mu+
|
↓
|
|
#797; HPV-
|
D-
|
Normal
|
Normal
|
D+Me+Mu-
|
↓
|
|
Hep2, HPV18
|
D-
|
Normal
|
Normal
|
D-Me+Mu-
|
↓
|
|
UPCI:SCC084, HPV-
|
D-
|
Normal
|
Normal
|
D-Me+Mu-
|
↓
|
- L: Dysplastic lesions; # HNSCC samples; D: Deletion; Me: Methylation; Mu: Mutation; '+': Positive; '-': Negative; '↓': Down expression; ND: Not done.
