Table 6 Correlation between mRNA and protein expression of RB1 and their association with LIMD1 molecular alterations.
RB1 | LIMD1 | ||||
|---|---|---|---|---|---|
Sample No.; HPV status | Genetic alterations | mRNA status | Protein expression | Genetic/epigenetic alterations | mRNA status |
Dysplastic lesions | |||||
L127; HPV- | D- | ND | Normal | D+Me+Mu- | ND |
L139; HPV- | D- | ND | Normal | D-Me+Mu- | ND |
L154; HPV- | D- | ND | Normal | D+Me+Mu- | ND |
L162; HPV- | D- | ND | Normal | D+Me+Mu- | ND |
L158; HPV16 | D- | ND | Medium | D+Me+Mu- | ND |
HNSCC samples | |||||
#1004; HPV- | D- | Normal | Normal | D+Me+Mu- | ↓ |
#5165; HPV- | D- | Normal | Normal | D+Me+Mu- | ↓ |
#6817;HPV16 | D+ | ↓ | Medium | D+Me+Mu- | ↓ |
#2884; HPV- | D- | Normal | Normal | D-Me-Mu- | Normal |
#1108; HPV - | D+ | ↓ | Medium | D-Me+Mu+ | ↓ |
#1774;HPV16 | D+ | ↓ | Low | D-Me+Mu+ | ↓ |
#872; HPV- | D- | Normal | Normal | D-Me-Mu- | Normal |
#5303; HPV- | D- | Normal | Normal | D-Me+Mu+ | ↓ |
#6907;HPV16 | D- | ↓ | Low | D-Me+Mu- | ↓ |
#1087; HPV- | D- | Normal | Normal | D-Me-Mu+ | Normal |
#944; HPV- | D+ | ↓ | Low | D+Me+Mu+ | ↓ |
#5733;HPV16 | D- | Normal | Normal | D+Me+Mu- | ↓ |
#6392; HPV- | D- | Normal | Normal | D-Me+Mu- | ↓ |
#7077; HPV- | D- | Normal | Normal | D-Me-Mu+ | ↓ |
#797; HPV- | D- | Normal | Normal | D+Me+Mu- | ↓ |
Hep2, HPV18 | D- | Normal | Normal | D-Me+Mu- | ↓ |
UPCI:SCC084, HPV- | D- | Normal | Normal | D-Me+Mu- | ↓ |