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Figure 2 | Molecular Cancer

Figure 2

From: Epidermal growth factor receptor regulates β-catenin location, stability, and transcriptional activity in oral cancer

Figure 2

Effects of EGFR signal on the phosphorylation and function of β-catenin and GSK-3β. (A) AG1478 treatment of SAS cells decreased phosphorylation of GSK-3β (Ser-9) and β-catenin (Tyr). EGF treatment of OECM1 cells increased phosphorylation of GSK-3β (Ser-9) and β-catenin (Tyr), as determined by immunoprecipitation of GSK-3β or β-catenin. (B) In SAS cells, association of E-cadherin and β-cadherin increased following treatment with AG1478; in OECM1 cells, association of E-cadherin and β-catenin decreased following treatment with EGF as determined by immunoprecipitation of E-cadherin or β-catenin.

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Molecular Cancer

ISSN: 1476-4598