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Figure 5 | Molecular Cancer

Figure 5

From: Epidermal growth factor receptor regulates β-catenin location, stability, and transcriptional activity in oral cancer

Figure 5

Immunohistochemical staining of EGFR, β-catenin, and cyclin D1 in oral cancer and adjacent normal tissues. EGFR-positive cells located in the basal and parabasal layer of a normal epithelium (A). β-catenin exhibited homogeneous expression in the membrane (B), and cyclin D1 expression was weak/undectectable (C). In tumor tissues, there was an increase of intensity and percentage of EGFR staining (D) and a loss of membranous stain (arrow head), increased cytoplasmic and nuclear accumulation (arrow) of β-catenin (E), and increased positive-staining cells of cyclin D1 (F). (Original magnifications; A, D: ×-20; B, E: ×-100; C, F: ×-400)

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