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Figure 2 | Molecular Cancer

Figure 2

From: Uncoupled responses of Smad4-deficient cancer cells to TNFα result in secretion of monomeric laminin-γ2

Figure 2

Synergistic effect of TGFβ and TNFα on the secretion of heterotrimeric laminin-332 by Smad4-reconstituted human colorectal cancer cells and uncoupled responses of Smad4-deficient cells. (A and B) Western blot analysis of proteins from conditioned media (12 μg of protein per lane) produced by SW480 (A) and SW620 (B) cells as described in figure 1. (C) Northern Blot analysis with RNAs from SW620 cells treated with cytokines for 4 h. Shown in each bar is the mean +/- standard error (n = 3). The additional file 2 provides additional data for SW620 cells treated with cytokines for 24 hours and data for SW480 cells treated with cytokines for 4 and 24 hours.

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Molecular Cancer

ISSN: 1476-4598