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Figure 1 | Molecular Cancer

Figure 1

From: Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway

Figure 1

MA enhances cell proliferation inhibition mediated by TNFα. (A) Structure of Maslinic Acid (MA) [(2α, 3β)-2, 3-dihydroxyolean-12-en-28-oic acid]. (B) MA potentiates TNFα-mediated cell growth inhibitory in different pancreatic cancer cell lines. TNFα inhibits cell proliferation in a dose-dependent manner and this inhibitory effect was significantly increased by 10 microM MA (left). And MA inhibits cell proliferation in a dose-dependent manner in the presence of a non-growth inhibitory dose of TNFα (0.1 nM) (right). Cell proliferation was evaluated by MTS method as suggested by the manufacture. Points, means of three experiments carried out in triplicate; bars, SD. * P < 0.05,**, P < 0.01, ***, P < 0.001 versus MA or TNF alone treated group. (C) MA potentiates TNFα-mediated cell growth inhibition in AsPC-1 and BxPC-3 pancreatic cancer cell lines in a dose-dependent manner. Cell growth was evaluated by MTS method. Points, means of three experiments carried out in triplicate; bars, SD. * P < 0.05, **, P < 0.01, ***, P < 0.001 versus MA or TNF.alone treated group.

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Molecular Cancer

ISSN: 1476-4598