Molecular networks representing the RFS gene expression signature (91 genes) in HCC patients with late (>1 year) recurrence. See Additional file 1, Table S7 for a complete list of significant networks. (A) HNF4α- and IFNγ-centered interactomes are top two most significant and interconnected (orange arrows) networks. (B) TP53-centered interactome is the top third significant network. Red and blue colors indicate positive or negative correlation, respectively, of gene expressions to recurrence-free survival based on Cox score. Ellipse, square, triangle, trapezoid, lozenge and circle represent transcription regulator, cytokine, kinase, transporter, enzyme and other molecules, respectively. Red and white represent molecules up-regulated in tumor samples compared to control and molecules incorporated into the network, respectively. Arrows connecting molecules indicate one molecule acts on another and lines indicate one binds to another. Dashed arrows or lines indicate indirect interactions of two molecules.