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Table 3 Association of gene expression poor-prognosis signature and clinical variables with late (>1 year) recurrence from univariate or multivariate analyses.

From: Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma

Variable Risk ratio 95% CI P-value
Univariate Cox proportional hazard model    
RFS signature (11 genes) 3.13 1.75-6.58 <0.0001
RFS signature (38 genes) 2.05 1.24-3.54 0.005
RFS signature (91 genes) 1.64 1.02-2.71 0.04
Tumor diameter [cm] 2.19 1.20-3.95 0.01
Number of tumors 4.28 1.24-13.39 0.02
Platelet count [104/μL] 0.91 0.80-1.02 0.11
Portal vein invasion [present] 0.00 0.00-1.93 0.15
Total bilirubin [mg/dL] 1.54 0.37-4.97 0.52
Age 1.02 0.96-1.10 0.53
Alanine aminotransferase [IU/L] 0.99 0.97-1.01 0.55
Indocyanine green [%] 1.02 0.95-1.08 0.56
Prothrombin time [%] 0.99 0.96-1.03 0.64
Liver resection procedure [lobular] 1.16 0.46-2.21 0.71
Fibrosis score 0.93 0.52-1.72 0.80
α-Fetoprotein [ng/μL] 1.00 1.00-1.00 0.85
Tumor differentiation [moderate-poor] 0.91 0.32-3.27 0.87
Sex [Male] 0.93 0.35-2.71 0.89
Multivariate Cox proportional hazard model    
RFS signature (11 genes) 3.38 1.75-7.77 0.0001
Number of tumors 8.55 1.87-46.69 0.006
Tumor diameter [cm] 1.68 0.92-3.19 0.09
RFS signature (38 genes) 1.84 1.08-3.23 0.02
Number of tumors 4.59 1.23-16.11 0.02
Tumor diameter [cm] 2.12 1.15-4.03 0.02
RFS signature (91 genes) 1.53 0.93-2.60 0.09
Number of tumors 3.58 0.98-12.3 0.05
Tumor diameter [cm] 2.46 1.30-4.70 0.006
  1. Cox proportional hazard model analysis was used to assess relative risk for each clinical variable or RFS gene expression signature. Relative risk >1 identifies shortened recurrence-free survival. Significant variables are highlighted in bold font.