Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma

Table 3 Association of gene expression poor-prognosis signature and clinical variables with late (>1 year) recurrence from univariate or multivariate analyses.

Variable	Risk ratio	95% CI	P-value
Univariate Cox proportional hazard model
RFS signature (11 genes)	3.13	1.75-6.58	<0.0001
RFS signature (38 genes)	2.05	1.24-3.54	0.005
RFS signature (91 genes)	1.64	1.02-2.71	0.04
Tumor diameter [cm]	2.19	1.20-3.95	0.01
Number of tumors	4.28	1.24-13.39	0.02
Platelet count [10⁴/μL]	0.91	0.80-1.02	0.11
Portal vein invasion [present]	0.00	0.00-1.93	0.15
Total bilirubin [mg/dL]	1.54	0.37-4.97	0.52
Age	1.02	0.96-1.10	0.53
Alanine aminotransferase [IU/L]	0.99	0.97-1.01	0.55
Indocyanine green [%]	1.02	0.95-1.08	0.56
Prothrombin time [%]	0.99	0.96-1.03	0.64
Liver resection procedure [lobular]	1.16	0.46-2.21	0.71
Fibrosis score	0.93	0.52-1.72	0.80
α-Fetoprotein [ng/μL]	1.00	1.00-1.00	0.85
Tumor differentiation [moderate-poor]	0.91	0.32-3.27	0.87
Sex [Male]	0.93	0.35-2.71	0.89
Multivariate Cox proportional hazard model
RFS signature (11 genes)	3.38	1.75-7.77	0.0001
Number of tumors	8.55	1.87-46.69	0.006
Tumor diameter [cm]	1.68	0.92-3.19	0.09
RFS signature (38 genes)	1.84	1.08-3.23	0.02
Number of tumors	4.59	1.23-16.11	0.02
Tumor diameter [cm]	2.12	1.15-4.03	0.02
RFS signature (91 genes)	1.53	0.93-2.60	0.09
Number of tumors	3.58	0.98-12.3	0.05
Tumor diameter [cm]	2.46	1.30-4.70	0.006

Cox proportional hazard model analysis was used to assess relative risk for each clinical variable or RFS gene expression signature. Relative risk >1 identifies shortened recurrence-free survival. Significant variables are highlighted in bold font.

ISSN: 1476-4598