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Figure 2 | Molecular Cancer

Figure 2

From: Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

Figure 2

Over-expression of survivin in various 17-AAG/geldanamycin-treated human cancer cell lines. (A) Human HONE-1 cancer cells were treated with various concentrations of 17-AAG/geldanamycin for 24 hours. Cell lysate was prepared after the treatment and various proteins were resolved by SDS-PAGE. The expression of Akt and survivin was revealed by Western blot analysis. Actin was used as an internal control. Relative ratio of expression was shown. (B) Human HT-29 cancer cells were treated with various concentrations of 17-AAG/geldanamycin for 24 hours. Cell lysate was prepared after the treatment and various proteins were resolved by SDS-PAGE. The expression of Akt and survivin was revealed by Western blot analysis. Actin was used as an internal control. Relative ratio of expression was shown.

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