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Figure 8 | Molecular Cancer

Figure 8

From: Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

Figure 8

Down-regulation of survivin enhanced the sensitivity to Hsp90 inhibitor in various cancer cells. A549 (A), HT-29 (B) and HONE-1 (C) cells were transfected with siR-C (scramble control) and siR-S (survivin specific) siRNA oligomers for 48 h and subsequently incubated with/without 250 nM of 17-AAG for 24 h. MTT cell viability assay was used to determine the viability of various treatments treated cells. Statistical significance (p < 0.05) between experimental samples is denoted by "*".

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Molecular Cancer

ISSN: 1476-4598