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PY - 2007 DA - 2007// TI - Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group JO - J Clin Oncol VL - 25 UR - https://doi.org/10.1200/JCO.2006.07.9525 DO - 10.1200/JCO.2006.07.9525 ID - Moore2007 ER - TY - JOUR AU - Yang, X. J. AU - Seto, E. PY - 2008 DA - 2008// TI - The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men JO - Nat Rev Mol Cell Biol VL - 9 UR - https://doi.org/10.1038/nrm2346 DO - 10.1038/nrm2346 ID - Yang2008 ER - TY - JOUR AU - Buchwald, M. AU - Krämer, O. H. AU - Heinzel, T. PY - 2009 DA - 2009// TI - HDACi--targets beyond chromatin JO - Cancer Lett VL - 280 UR - https://doi.org/10.1016/j.canlet.2009.02.028 DO - 10.1016/j.canlet.2009.02.028 ID - Buchwald2009 ER - TY - JOUR AU - Spange, S. AU - Wagner, T. AU - Heinzel, T. AU - Krämer, O. H. PY - 2009 DA - 2009// TI - Acetylation of non-histone proteins modulates cellular signalling at multiple levels JO - Int J Biochem Cell Biol VL - 41 UR - https://doi.org/10.1016/j.biocel.2008.08.027 DO - 10.1016/j.biocel.2008.08.027 ID - Spange2009 ER - TY - JOUR AU - Witt, O. AU - Deubzer, H. E. AU - Milde, T. AU - Oehme, I. PY - 2009 DA - 2009// TI - HDAC family: What are the cancer relevant targets? JO - Cancer Lett VL - 277 UR - https://doi.org/10.1016/j.canlet.2008.08.016 DO - 10.1016/j.canlet.2008.08.016 ID - Witt2009 ER - TY - JOUR AU - Glozak, M. A. AU - Seto, E. PY - 2007 DA - 2007// TI - Histone deacetylases and cancer JO - Oncogene VL - 26 UR - https://doi.org/10.1038/sj.onc.1210610 DO - 10.1038/sj.onc.1210610 ID - Glozak2007 ER - TY - CHAP AU - Schneider, G. AU - Krämer, O. H. AU - Fritsche, P. AU - Schüler, S. AU - Schmid, R. M. AU - Saur, D. 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PY - 2001 DA - 2001// TI - Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells JO - Embo J VL - 20 UR - https://doi.org/10.1093/emboj/20.24.6969 DO - 10.1093/emboj/20.24.6969 ID - Göttlicher2001 ER - TY - JOUR AU - Krämer, O. H. AU - Zhu, P. AU - Ostendorff, H. P. AU - Golebiewski, M. AU - Tiefenbach, J. AU - Peters, M. A. AU - Brill, B. AU - Groner, B. AU - Bach, I. AU - Heinzel, T. AU - Göttlicher, M. PY - 2003 DA - 2003// TI - The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2 JO - Embo J VL - 22 UR - https://doi.org/10.1093/emboj/cdg315 DO - 10.1093/emboj/cdg315 ID - Krämer2003 ER - TY - JOUR AU - Igney, F. H. AU - Krammer, P. H. PY - 2002 DA - 2002// TI - Death and anti-death: tumour resistance to apoptosis JO - Nat Rev Cancer VL - 2 UR - https://doi.org/10.1038/nrc776 DO - 10.1038/nrc776 ID - Igney2002 ER - TY - JOUR AU - Fulda, S. AU - Debatin, K. M. 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PY - 2008 DA - 2008// TI - Directing cancer cells to self-destruct with pro-apoptotic receptor agonists JO - Nat Rev Drug Discov VL - 7 UR - https://doi.org/10.1038/nrd2637 DO - 10.1038/nrd2637 ID - Ashkenazi2008 ER - TY - JOUR AU - Newsom-Davis, T. AU - Prieske, S. AU - Walczak, H. PY - 2009 DA - 2009// TI - Is TRAIL the holy grail of cancer therapy? JO - Apoptosis VL - 14 UR - https://doi.org/10.1007/s10495-009-0321-2 DO - 10.1007/s10495-009-0321-2 ID - Newsom-Davis2009 ER - TY - JOUR AU - Sanlioglu, A. D. AU - Dirice, E. AU - Elpek, O. AU - Korcum, A. F. AU - Balci, M. K. AU - Omer, A. AU - Griffith, T. S. AU - Sanlioglu, S. PY - 2008 DA - 2008// TI - High levels of endogenous tumor necrosis factor-related apoptosis-inducing ligand expression correlate with increased cell death in human pancreas JO - Pancreas VL - 36 UR - https://doi.org/10.1097/MPA.0b013e318158a4e5 DO - 10.1097/MPA.0b013e318158a4e5 ID - Sanlioglu2008 ER - TY - JOUR AU - Sanlioglu, A. D. AU - Dirice, E. 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PY - 2007 DA - 2007// TI - The promise of TRAIL--potential and risks of a novel anticancer therapy JO - J Mol Med VL - 85 UR - https://doi.org/10.1007/s00109-007-0194-1 DO - 10.1007/s00109-007-0194-1 ID - Koschny2007 ER - TY - JOUR AU - Vogler, M. AU - Durr, K. AU - Jovanovic, M. AU - Debatin, K. M. AU - Fulda, S. PY - 2007 DA - 2007// TI - Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells JO - Oncogene VL - 26 UR - https://doi.org/10.1038/sj.onc.1209776 DO - 10.1038/sj.onc.1209776 ID - Vogler2007 ER - TY - JOUR AU - Lehmann, A. AU - Denkert, C. AU - Budczies, J. AU - Buckendahl, A. C. AU - Darb-Esfahani, S. AU - Noske, A. AU - Muller, B. M. AU - Bahra, M. AU - Neuhaus, P. AU - Dietel, M. PY - 2009 DA - 2009// TI - High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo JO - BMC Cancer VL - 9 UR - https://doi.org/10.1186/1471-2407-9-395 DO - 10.1186/1471-2407-9-395 ID - Lehmann2009 ER - TY - JOUR AU - Weichert, W. PY - 2009 DA - 2009// TI - HDAC expression and clinical prognosis in human malignancies JO - Cancer Lett VL - 280 UR - https://doi.org/10.1016/j.canlet.2008.10.047 DO - 10.1016/j.canlet.2008.10.047 ID - Weichert2009 ER - TY - JOUR AU - Marchion, D. C. AU - Bicaku, E. AU - Turner, J. G. AU - Schmitt, M. L. AU - Morelli, D. R. AU - Munster, P. N. PY - 2009 DA - 2009// TI - HDAC2 regulates chromatin plasticity and enhances DNA vulnerability JO - Mol Cancer Ther VL - 8 UR - https://doi.org/10.1158/1535-7163.MCT-08-0985 DO - 10.1158/1535-7163.MCT-08-0985 ID - Marchion2009 ER - TY - JOUR AU - Bicaku, E. AU - Marchion, D. C. AU - Schmitt, M. L. AU - Munster, P. N. PY - 2008 DA - 2008// TI - Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-07-2822 DO - 10.1158/0008-5472.CAN-07-2822 ID - Bicaku2008 ER - TY - JOUR AU - Kaler, P. AU - Sasazuki, T. AU - Shirasawa, S. AU - Augenlicht, L. AU - Klampfer, L. PY - 2008 DA - 2008// TI - HDAC2 deficiency sensitizes colon cancer cells to TNFalpha-induced apoptosis through inhibition of NF-kappaB activity JO - Exp Cell Res VL - 314 UR - https://doi.org/10.1016/j.yexcr.2008.01.010 DO - 10.1016/j.yexcr.2008.01.010 ID - Kaler2008 ER - TY - JOUR AU - von Burstin, J. AU - Eser, S. AU - Paul, M. C. AU - Seidler, B. AU - Brandl, M. AU - Messer, M. AU - von Werder, A. AU - Schmidt, A. AU - Mages, J. AU - Pagel, P. 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PY - 2008 DA - 2008// TI - Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic cancer growth in vitro and in vivo JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-08-1296 DO - 10.1158/0008-5472.CAN-08-1296 ID - Vogler2008 ER - TY - JOUR AU - Vogler, M. AU - Walczak, H. AU - Stadel, D. AU - Haas, T. L. AU - Genze, F. AU - Jovanovic, M. AU - Bhanot, U. AU - Hasel, C. AU - Moller, P. AU - Gschwend, J. E. PY - 2009 DA - 2009// TI - Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma JO - Cancer Res VL - 69 UR - https://doi.org/10.1158/0008-5472.CAN-08-2436 DO - 10.1158/0008-5472.CAN-08-2436 ID - Vogler2009 ER - TY - JOUR AU - Mori, T. AU - Doi, R. AU - Kida, A. AU - Nagai, K. AU - Kami, K. AU - Ito, D. AU - Toyoda, E. AU - Kawaguchi, Y. AU - Uemoto, S. 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