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Figure 6 | Molecular Cancer

Figure 6

From: Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma

Figure 6

A model of glycolysis illustrating the possible involvement in cellular energy signaling pathways. Arrows represent activation, whereas bars represent inhibition. Dotted arrows indicate the increased ratio of AMP/ATP. Small circles represent ATP. AMPK, AMP-activated protein kinase; TSC, tuberous sclerosis complex; Rheb, Ras homologue enriched in brain; mTOR, mammalian target of rapamycin; S6K, ribosomal protein S6 kinases; 4E-BP1, eIF4E-binding protein; ACC, acetyl-CoA carboxylase; FASN, fatty-acid synthase; CDKs, cyclin dependent kinases.

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