Figure 6From: Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinomaA model of glycolysis illustrating the possible involvement in cellular energy signaling pathways. Arrows represent activation, whereas bars represent inhibition. Dotted arrows indicate the increased ratio of AMP/ATP. Small circles represent ATP. AMPK, AMP-activated protein kinase; TSC, tuberous sclerosis complex; Rheb, Ras homologue enriched in brain; mTOR, mammalian target of rapamycin; S6K, ribosomal protein S6 kinases; 4E-BP1, eIF4E-binding protein; ACC, acetyl-CoA carboxylase; FASN, fatty-acid synthase; CDKs, cyclin dependent kinases.Back to article page