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Table 2 Proteins identified by LC MS/MS.

From: Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma

Protein namea

Gene name

Accession no.b

Theotetical molecular mass/PIc

Queries matched

Sequence

coverage (%)

MOWSE scored

Fold changee

Function

Up-regulation

        

Macrophage migration inhibitory factor

MIF

P14174

12642/7.74

1

9

57

3.1 ± 0.9

Immune regulation

Peptidyl-prolyl cis-trans isomerase A

PPIA

P62937

18233/7.68

12

35

238

8.7 ± 2.2

Protein folding

Eukaryotic translation initiation factor 5A-1

IF5A1

P63241

17053/5.08

3

22

214

2.1 ± 0.9

Translation regulation

Histone H2A.V

H2AV

Q71UI9

13501/10.58

2

28

138

3.9 ± 1.1

Transcription regulation

Phosphatidylethanolamine-binding protein 1

PEBP1

P30086

21160/7.01

2

18

92

2.9 ± 0.9

Signal transduction

Peroxiredoxin-6

PRDX6

P30041

25135/6.00

8

40

175

3.1 ± 1.2

Metabolism

Phosphoglycerate mutase 1

PGAM1

P18669

28902/6.67

8

38

172

6.0 ± 1.4

Metabolism

14-3-3 protein zeta/delta

1433Z

Q6P3U9

27902/4.73

9

33

126

3.3 ± 1.2

Signal transduction

Triosephosphate isomerase

TPIS

P60174

26943/6.45

21

45

406

2.9 ± 0.8

Metabolism

Proteasome activator complex subunit 1

PSME1

Q06323

28879/5.78

1

7

59

6.7 ± 2.1

Proteolysis

Enoyl-CoA hydratase, mitochondrial

ECHM

P30084

31831/8.34

1

7

51

2.6 ± 0.8

Metabolism

Annexin A4

ANXA4

P09525

36092/5.84

1

5

98

2.4 ± 0.5

Signal transduction

Annexin A5

ANXA5

P08758

35972/4.94

2

8

52

3.7 ± 1.5

Signal transduction

Aldo-keto reductase family 1 member C1

AK1C1

Q04828

37229/8.02

4

24

109

11.7 ± 2.7

Metabolism

Aldo-keto reductase family 1 member C3

AK1C3

Q9UKL9

37227/8.05

2

10

58

8.1 ± 2.4

Metabolism

Alpha-enolase

ENOA

Q6GMP2

47487/7.01

20

27

485

7.8 ± 1.9

Metabolism

Keratin, type I cytoskeletal 19

K1C19

Q9P1Y4

44065/5.04

17

32

344

5.8 ± 1.9

Structural component

Keratin, type I cytoskeletal 18

K1C18

P05783

48029/5.34

17

12

285

5.1 ± 1.7

Structural component

Phosphoglycerate kinase 1

PGK1

P00558

44992/8.30

6

13

73

18.3 ± 4.3

Metabolism

Isocitrate dehydrogenase [NADP] cytoplasmic

IDHC

O75874

46920/6.53

1

3

53

2.6 ± 0.3

Metabolism

Keratin, type II cytoskeletal 8

K2C8

Q96J60

53671/5.52

18

26

273

5.1 ± 1.3

Structural component

60 kDa heat shock protein, mitochondrial

CH60

P10809

61190/5.70

18

23

477

10 ± 3.4

Molecular chaperone

UDP-glucose 6-dehydrogenase

UGDH

O60701

5685/6.73

2

8

75

3.1 ± 1.1

Metabolism

Glutamate dehydrogenase 1

GLUD1

P00367

61701/7.66

4

26

187

8.3 ± 2.6

Metabolism

Aminoacylase-1

ACY1

Q03154

46084/5.77

6

25

246

4.7 ± 1.9

Proteolysis

Glutathione transferase omega-1

GSTO1

P78417

27833/6.24

7

18

264

8.3 ± 2.4

Metabolism

Ubiquitin

UBC

P62988

8560/6.56

7

9

156

2.7 ± 0.8

Proteolysis

Cofilin-1

COF1

P23528

18723/8.22

6

27

306

2.6 ± 1.1

Signal transduction

Acidic leucine-rich nuclear phosphoprotein 32 family member B

AN32B

Q92688

28944/3.94

4

19

136

4.1 ± 1.4

Protein binding

Annexin A3

ANXA3

P12429

36527/5.63

3

12

85

13.5 ± 2.7

Signal transduction

Histone H1.2

H12

P16403

21352/10.94

3

6

54

9.5 ± 2.4

Protein binding

Glyceraldehyde-3-phosphate dehydrogenase

G3P

P04406

36204/8.57

63

59

1299

8.1 ± 2.7

Metabolism

Aldose reductase

ALDR

P15121

36237/6.51

11

25

240

8.5 ± 3.1

Protein binding

Aldo-keto reductase family 1 member C2

AK1C2

P52895

37118/7.13

5

20

229

14.8 ± 4.5

Metabolism

Aldo-keto reductase family 1 member B10

AK1BA

O60218

36230/7.12

3

13

131

13.1 ± 3.8

Metabolism

Complement component 1 Q subcomponent-binding protein, mitochondrial

C1QBP

Q07021

31749/4.74

2

10

78

13.3 ± 3.7

Immune regulation

60S ribosomal protein L6

RL6

Q02878

32766/10.59

11

26

202

11.3 ± 3.7

Transcription regulation

Poly(rC)-binding protein 2

PCBP2

Q15366

38962/6.33

3

13

62

10.2 ± 2.4

Protein binding

Heat shock 70 kDa protein 1

HSP71

P08107

70299/5.48

4

8

115

20.4 ± 4.8

Molecular chaperone

Trifunctional enzyme subunit alpha, mitochondrial

ECHA

P40939

83701/9.16

4

8

98

3.8 ± 1.9

Metabolism

Annexin A6

ANXA6

P08133

76174/5.42

4

3

92

11.4 ± 3.2

Signal transduction

Heat shock 70 kDa protein 1L

HS71L

P34931

70737/5.76

4

6

84

29.5 ± 5.7

Molecular chaperone

Protein disulfide-isomerase A4

PDIA4

P13667

73235/4.96

3

4

81

11.4 ± 3.6

Metabolism

ATP synthase subunit beta, mitochondrial

ATPB

P06576

56525/5.26

14

28

352

22.7 ± 4.9

Metabolism

Pyruvate kinase isozymes M1/M2

KPYM

Q9BWB5

58480/7.96

12

23

334

2.3 ± 1.4

Metabolism

Protein disulfide-isomerase

PDIA1

P07237

57487/4.76

3

5

84

8.8 ± 3.6

Protein binding

Delta-1-pyrroline-5-carboxylate synthetase

P5CS

P54886

88002/6.66

6

6

178

14.3 ± 4.1

Metabolism

Desmoplakin

DESP

P15924

334063/6.44

3

2

64

3.3 ± 1.6

Structural component

ATP-dependent DNA helicase 2 subunit 2

KU86

P13010

83232/5.55

3

7

53

9.6 ± 3.5

Protein binding

Cullin-associated NEDD8-dissociated protein 1

CAND1

Q9P0H7

138029/5.52

6

3

63

4.1 ± 2.1

Transcription regulation

ATP-dependent DNA helicase 2 subunit 1

KU70

P12956

70089/6.23

9

5

107

3.1 ± 1.6

Protein binding

Down-regulation

        

Protein S100-A6

S100A6

P06703

10231/5.33

2

28

53

3.8 ± 1.4

Calcium ion binding

Calpain small subunit 1

CAPNS1

P04632

28469/5.05

4

13

157

3.1 ± 1.6

Calcium ion binding

Annexin A1

ANXA1

P04083

38922/6.57

2

4

98

2.7 ± 0.8

Calcium ion binding

Interleukin-18 precursor (IL-18)

IL18

Q14116

22597/4.54

12

18

123

2.3 ± 0.6

Immune regulation

Transketolase

TKT

P29401

68531/7.58

9

13

145

6.2 ± 1.9

Metabolism

Profilin-1

PFN1

P07737

15219/8.44

6

21

140

3.4 ± 1.7

Structural component

Pyruvate dehydrogenase E1 component alpha subunit

PDHA1

P08559

43296/8.35

14

8

179

3.5 ± 1.5

Metabolism

Protein SET

SET

Q01105

33469/4.23

2

16

96

4.4 ± 1.7

Signal transduction

Heat shock protein HSP 90-alpha

HS90A

P07900

85013/4.94

40

26

428

2.8 ± 0.5

Molecular chaperone

Histone H2A type 2-A

H2A2A

Q6FI13

14087/10.90

6

36

153

3.7 ± 1.2

Transcription regulation

Poly(rC)-binding protein 1

PCBP1

Q15365

37996/6.66

9

17

118

2.6 ± 1.4

Protein binding

Lamin-A/C

LMNA

P02545

74385/6.57

7

11

86

3.7 ± 1.8

Protein binding

  1. aFor several proteins, a few isoforms were identified in the same individual.
  2. bAccession numbers were derived from the ExPASy database.
  3. cTheoretical molecular mass (kDa) and pI from the ExPASy database.
  4. dProbability-based MOWSE (molecular weight search) scores.
  5. eExpression change level in HepG2 cells compared with L02 cells.
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Molecular Cancer

ISSN: 1476-4598