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Figure 3 | Molecular Cancer

Figure 3

From: PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells

Figure 3

PI3K regulation of PCa cell migration and invasion. LNCaP and PC3 cell lines were tested for their ability to invade Matrigel™ Matrix and migrate through an 8.0 μm porous membrane in the presence of CXCL13 and/or wortmannin, PI-103, TGX-221 and AS605240, U73122, or DOCK2 siRNA. Cells that invaded or migrated to the lower surface of the membrane were stained with crystal violet and counted by microscopy at 40× magnification. Percent cell invasion was calculated following manufacturer's instructions (BD Biosciences). Asterisks indicate significant differences (p < 0.05) with CXCL13-treated cells.

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