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Figure 7 | Molecular Cancer

Figure 7

From: PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells

Figure 7

CXCR5 activate PI3K isoforms through Gα-Src-FAK pathway or via Gβ/γ pathway leading to subsequent activation of ERK1/2. LNCaP cells express PI3Kp110α, PI3Kp110β and PI3Kp110δ, while PC3 cells express PI3Kp110α, PI3Kp110β and PI3Kp110γ. Perhaps owing to their more aggressive phenotype, PC3 cells are capable of exploiting both Gα-Src-FAK and Gβ/γ-mediated events leading to enhanced migration and invasion, while LNCaP cells are only able to take advantage of the Gα-Src-FAK-mediated pathway following CXCL13-CXCR5 interaction.

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Molecular Cancer

ISSN: 1476-4598