Skip to main content

Table 1 Percentage of U1690 cells with decreased mitochondrial membrane potential, active Bax and subdiploid DNA content.

From: Doxorubicin and etoposide sensitize small cell lung carcinoma cells expressing caspase-8 to TRAIL

% of cells

Control

TRAIL

Doxorubicin

TRAIL+Doxorubicin

Decreased MMP

2.3 ± 0.6

2.2 ± 0.7

13.4 ± 1.8 *

29.8 ± 6.3 *+x

Active Bax

1.5 ± 0.9

2.8 ± 0.4

11.9 ± 3.5 *

44.1 ± 5.3 *+x

Sub-G1

4.9 ± 0.6

5.2 ± 0.5

21.9 ± 3.4 +*

40.4 ± 1.7 *+x

  1. Cells were treated (24 h) with TRAIL (100 ng/ml), doxorubicin (1 μM) or their combination. Results are means ± S.E.M. of three independent experiments. Statistical significance: P < 0.05, (*) versus control, (+) versus TRAIL, (x) versus doxorubicin. MMP - mitochondrial membrane potential.