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Figure 3 | Molecular Cancer

Figure 3

From: Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells

Figure 3

Cyclopamine prevents the development of AI prostate cancer cell growth and suppresses the growth of LNCaP-AI cells. (A) Phase contrast photomicrographs (40×) of LNCaP cells cultured for 60 days in androgen depleted medium (CS-FBS) supplemented with vehicle (EtOH) or 5 μM cyclopamine (Cyclo). Cell numbers in cyclopamine are greatly reduced and cells have optically dense, fragmented nuclei. (B) LNCaP-AI cells grown in androgen-depleted medium (CS-FBS) supplemented with vehicle (EtOH) or 5 μM cyclopamine. Cell numbers were counted at various days as indicated. Points represent the means of triplicate cultures ± S.E.

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