Skip to main content
Figure 6 | Molecular Cancer

Figure 6

From: Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-β2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A

Figure 6

DNMT3A shRNA antagonized BPDE's effect on gene expression to different levels. Esophageal cancer SKGT-4 and TE3 cells were grown and transiently transfected with the empty vector or DNMT3A shRNA-3 vector for 48 h. The cells were then treated with or without 1 μM BPDE for 12 h, and the total cellular protein was extracted and subjected to Western blotting analysis of c-Jun, phosphorylated-ERK1/2 and COX-2 expression.

Back to article page

Molecular Cancer

ISSN: 1476-4598