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Figure 6 | Molecular Cancer

Figure 6

From: Application of magnetic resonance imaging in transgenic and chemical mouse models of hepatocellular carcinoma

Figure 6

Detection limits of HCC nodules in an alb-myctg mice. (A) In the un-enhanced T1-weighted gradient echo image of murine liver lesions are either not detectable or can be identified only faintly (white arrow). (B) Sagittal true-FISP image demonstrates slightly hyperintense lesion signals (green arrows). (C) In the contrast-enhanced T1 scan of the right hepatic lobes, multiple slightly hypointense lesions are visible (green arrow). These lesions cannot be clearly identified on the pre-contrast scan (A). (D) In the T2-weighted scan hyperintense space-occupying lesions can be seen in the murine liver (green arrows). (E) Surgical situs. View of two hepatic lobes in a sagittal orientation. Visualization of four nodules (green arrows) with 2 mm of diameter within non-tumorgenic liver tissue. Of note, corresponding signals were made visible by 3D true-FISP (compare B), T1-weighted contrast-enhanced (compare C) and T2-weighted (compare D) MR images, but not in un-enhanced T1-weighted image (compare A). Labeling of orientation: R: right; L: left; H: head; A: anterior; P: posterior; F: foot.

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