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Figure 4 | Molecular Cancer

Figure 4

From: Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network

Figure 4

Recurrent co-regulated gene networks in patient cancer samples. The set of Par-4-modulated genes with NFκB sites identified in HT29 colon cancer cells were analyzed in patient cancer sample microarray data to define recurrent co-regulated gene networks. (A) Colon cancer recurrent co-regulated network of 240 genes with 311 links. (B) Prostate cancer recurrent co-regulated network of 276 genes with 367 links. A subset of Par-4-modulated genes identified in HT29 cells can also be found in a recurrent co-regulated network in prostate cancer samples. This suggests that Par-4 co-regulates overlapping genes with NFκB sites in both colon and prostate cancer samples. Red and green nodes indicate genes that were found to be up- or down-regulated by Par-4 in HT29 cells, respectively.

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Molecular Cancer

ISSN: 1476-4598