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Figure 7 | Molecular Cancer

Figure 7

From: Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NFκB and microRNA network

Figure 7

DROSHA down-regulation sensitizes cells to apoptosis induced by 5-FU. Empty vector-expressing HT29 cells were transfected with scrambled or DROSHA siRNA for 48 h. (A) Quantitative RT-PCR results confirm that DROSHA expression was decreased (P < 0.05). Results are the mean ± S.D. of 4-5 independent experiments. (B) Knockdown of DROSHA increased apoptosis in response to 5-FU, as assayed with 7-AAD and Annexin V (P < 0.02). Results are the mean ± S.D. of 4-5 independent experiments.

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Molecular Cancer

ISSN: 1476-4598