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Figure 3 | Molecular Cancer

Figure 3

From: Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma

Figure 3

Effects of ethanol on the migration/invasion of HepG2 cells in vitro. (A) The migration of HepG2 cells was analyzed by the wound healing assay as described in the Materials and methods. HepG2 cells were exposed to ethanol (0.2%) with/without PDTC (20 μM) for 24 hours. Representative images of wound healing at 0 and 24 hours are shown. (B) Quantification of the migration of HepG2 cells. (C) The invasion of HepG2 cells was analyzed by a matrigel invasion assay. HepG2 cells were plated into the upper compartments of the matrigel invasion chambers and exposed to ethanol (0.2%) with/without PDTC (20 μM) or C3G (20 μM) for 48 hours. Images of cells migrating through the chambers were shown. (D) The cells migrated through the chamber were quantified. *P <0.05, **P <0.01, n = 3.

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