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Table 1 Differential effects of S100A7 overexpression in human breast cancer cell lines

From: miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer

Cell line

MDA-MB-231

MCF7

Cancer subtype

Basal-like

Luminal

ER status

ER negative

ER positive

Proliferation change with S100A7 overexpression

↑ 57%*

↓ 33%*

Morphology change with S100A7 overexpression

Gained mesenchymal

Gained epithelial

Tumor growth with S100A7 overexpression

↑ 1089%*

↓ 79%*

  1. Changes of cell proliferation, morphology, tumor formation in nude mice caused by S100A7 overexpression in given cell lines are listed. Mesenchymal properties of cell morphology include fibroblast-like cell shape, absence of cell-cell adhesion; epithelial properties include flat and scale-like cell shape, increased cell-cell adhesion and clustering. (*p < 0.05).
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Molecular Cancer

ISSN: 1476-4598